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Penicillin VK
Penicillin VK is the potassium salt of penicillin V (known as phenoxymethylpenicillin). It is indicated for the treatment of the following infections:
Dietary considerations Take preferably on an empty stomach 1 hour before or 2 hours after meals. Penicillin VK may be taken with meals, however food generally delays its absorption. Dosage Usual dosage range of penicillin VK:
Drug interactions
High urinary concentrations of penicillin may produce false positive or elevated test results with copper sulfate tests (Benedict’s, Clinitest or Fehling’s). Side effects The most common side effects:
Hypersensitivity reactions:
Mechanism of Action Penicillin V potassium is bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication. It produces its effect by inhibiting biosynthesis of cell-wall mucopeptide. It is not active against the penicillinase-producing bacteria, which include many strains of staphylococci. Penicillin V potassium has the distinct advantage over penicillin G (benzylpenicillin) in being resistant to inactivation by gastric acid. It may be given with meals; however, blood levels are slightly higher when the drug is given on an empty stomach. Contraindications
References:
Last Updated: September, 2013 Interesting facts
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