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Prescription Pain Medications


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Types of medications for pain management

Pain medications (analgesics) are a type of drugs used to relieve pain. Analgesics prevent the brain from processing pain signals by stopping pain signals from going to the brain or by altering the brain’s interpretation of those signals.

There are different types of pain medicines, and each one has advantages and risks. Specific types of pain may respond better to one kind of medication than to another kind. In choosing analgesics, the type of pain, severity, and response to other medication determine the choice of specific agent.

There are two basic types of pain relievers:

  • Non-narcotic pain medications, also known as non-opioids, are milder forms of analgesics and include acetaminophen, the most commonly used over the counter non-narcotic analgesic. Non-steroidal anti-inflammatory drugs (NSAIDs) are not technically analgesics, but are nonetheless considered analgesics in practice.
  • Narcotic pain medications, also known as opioids, are stronger analgesics that are used when pain signals are too severe to be controlled by non-narcotics. Analgesics in this category include natural narcotics (derived from the opium poppy), such as morphine and codeine, and synthetic narcotics, such as propoxyphene (Darvon) and meperidine (Demerol).

Pain medications are used to treat various acute and chronic pain conditions, including:

  • arthritis and other types of joint pain
  • headaches
  • migraine
  • sore muscles, muscular aches
  • menstrual cramps
  • back pain (including herniated discs, degenerative disc disease and spinal stenosis)
  • trauma pain (work-related, sports injuries)
  • childbirth pain
  • surgical pain
  • orofacial and dental pain
  • fibromyalgia
  • colds and flu

While pain relievers do not treat the cause of the pain, they can provide enough relief to improve physical, social and psychological measures of quality of life.

Acetaminophen (paracetamol)

Acetaminophen is a non-prescription mild analgesic. It is used to treat mild-to-moderate pain and reduce fever. Acetaminophen provides relief from pain by elevating the amount of pain you can tolerate before you experience the feeling of pain.

Medications for back and neck pain

Medications with good evidence of effectiveness for back pain are NSAIDs, skeletal muscle relaxants (for acute low back pain), and tricyclic antidepressants (for chronic low back pain). A challenge in choosing medication for low back pain is that each class of medication is associated with a unique balance of benefits and harms.

NSAIDs are widely used for the treatment of back and neck pain. These medications help with pain and inflammation, but don't address the underlying problem. Most guidelines recommend NSAIDs as a treatment option after acetaminophen has been tried. The choice of initial NSAID agent remains in most cases empirical. Newer medications usually cost significantly more.

  • Over-the-counter (OTC) NSAIDs include aspirin, ibuprofen (Advil, Rufen), naproxen (Aleve), ketoprofen (Actron).
  • Prescription NSAIDs include ibuprofen (Motrin), naproxen (Naprosyn), diclofenac (Voltaren), tolmetin (Tolectin), ketoprofen (Orudis, Oruvail), indomethacin (Indocin), ketorolac (Toradol), meclofenamate (Meclomen), nabumetone (Relafen), piroxicam (Feldene).
  • COX-2 inhibitors: celecoxib (Celebrex).

Although the selective COX-2 inhibitors have fewer side effectsthan traditional NSAIDs, recent research have shown that COX-2 inhibitors are associated with serious cardiovascular risks.

NSAIDs and acetaminophen work differently, so sometimes it is recommended to take both medications at the same time.

Tramadol (Ultram) is a powerful synthetic analgesic, which has opioid-like effects effective. It is effective pain reliever for both acute and chronic low back pain. Tramadol may be considered when non-opioid analgesics have proven ineffective.

The abuse and dependence potential for tramadol is relatively low. It can cause nausea, but does not cause the severe gastrointestinal problems that NSAIDs can.

A combination of tramadol plus acetaminophen (Ultracet) is also effective treatment for back pain. It provides more rapid pain relief than tramadol alone.

Muscle relaxants such as cyclobenzaprine (Flexeril), carisoprodol (Soma), or metaxalone (Skelaxin) are sometimes used for acute low back pain. They are effective in the treatment of muscle spasm and can improve movement. Some experts warn that these drugs should be used with caution, since they act centrally in the brain, not work directly on the muscles.

Opioids (also called narcotics) may be prescribed for short-term treatment of severe episodes of low back pain. These medications interfere with the transmission of pain messages and change the way a person experiences pain. Opioid agents have several major side effects and potential risks, such as impairment of mental function, drowsines, constipation, potential for abuse and dependence.

Pain medications for fibromyalgia

Fibromyalgia is a chronic condition that causes widespread muscle pain, myalgia, and excessive tenderness in many areas of the body.

  • Anticonvulsant pregabalin (Lyrica) was the first FDA-approved medication for fibromyalgia. Gabapentin (Neurontin) and other anticonvulsants are also used to treat fibromyalgia and may help to relieve pain and improve sleep. Anticonvulsants lead to an increase in GABA signaling, in effect turning the activity of nervous system down.
  • SNRIs antidepressants duloxetine (Cymbalta) and venlafaxine (Effexor) help relieve fibromyalgia pain. Duloxetine (Cymbalta) is the only antidepressant approved by the FDA to treat fibromyalgia pain. These medications affect two brain neurotransmitters, serotonin and norepinephrine.
  • Tricyclic antidepressants are often prescribed for fibromyalgia, but many people don't tolerate their side effects such as weight gain, dizziness, fatigue. These medications also can help with sleep.
  • Tramadol (Ultram) and Tramadol/acetaminophen (Ultracet) are effective for the treatment of fibromyalgia pain without any serious side effects. Tramadol can help break cycles of fibromyalgia pain, relieve flare-up pain, and reduce muscle spasms. Use of tramadol is less likely to result in addiction compared to other narcotic pain relievers.

Because fibromyalgia does not cause inflammation, it is not surprising that NSAIDs do not relieve fibromyalgia symptoms.

Opioid pain medications have not been studied for the treatment of fibromyalgia.

Pain medications for osteoporosis

Osteoporosis (porous bone) is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to weak bones prone to fractures. The most common cause of osteoporosis pain is a spinal compression fracture. Osteoporotic pain can last for long periods ranging from a few weeks to months.

Medication often prescribed to relieve osteoporosis pain include:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used treatments for osteoarthritis. NSAIDs have an essential difference from analgesics: while analgesics treat pain, NSAIDs treat both pain and inflammation.
  • Celecoxib (Celebrex) is the only COX-2 inhibitor available in the United States. COX-2 inhibitors differ from traditional NSAIDs by targeting only the pain-signaling prostaglandins. So they relieve pain without causing stomach problems often associated with NSAIDs. However, some COX-2 inhibitors, Vioxx and Bextra, have been withdrawn from the market after being linked to an increased risk of serious cardiovascular side effects.
  • Opioids can help in the short-term with moderate to severe acute pain.
  • Antidepressant medications are is sometimes used to help people cope with chronic pain. These medications may be prescribed when other forms of pain relief have not helped.

Medications for menstrual cramps

Most women often experience pain or cramps right before or during their menstrual periods. This is a very common and normal symptom called dysmenorrhea, which generally subsides as menstrual bleeding tapers off.

Medications useful for the management of painful menstruation (dysmenorrhea):

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) may be helpful in relieving the pain of menstrual cramps. Over-the-counter NSAIDs, such as ibuprofen (Advil, Motrin) and naproxen (Aleve) are usually very effective. For severe cramps that cannot be relieved with acetaminophen or OTC NSAIDs, prescription anti-inflammatories such as diclofenac (Voltaren), mefenamic acid (Ponstel), or indomethacin (Indocin) may alleviate dysmenorrhea.

Post-herpetic (shingles) pain management

Post-herpetic neuralgia is a persistent or recurrent pain lasting more than a month after the onset of shingles (herpes zoster).

Neuropathic pain due to herpes zoster is best treated with the antidepressants or antiepileptics:

  • Tricyclic antidepressants (amitriptyline, nortriptyline, imipramine)
  • SNRIs antidepressants (duloxetine, venlafaxine)
  • Anticonvulsants (gabapentin, carbamazepine, sodium valproate, pregabalin)

Although these medications will not restore nerve function, they will reduce the burning pain and discomfort in most persons.

Topical capsaicin and lidocaine patches applied to affected area are also used to treat post-herpetic neuralgia.

Over-the-counter analgesics such as acetaminophen and non-steroidal anti-inflammatory drugs are generally unhelpful.

Resources, References:

  • 1. Chou R, Huffman LH; Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med. 2007 Oct 2;147(7):505-14.
  • 2. Schnitzer TJ, Gray WL, Paster RZ, Kamin M. Efficacy of tramadol in treatment of chronic low back pain. J Rheumatol. 2000 Mar;27(3):772-8.

 


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